You spend months planning a cruise. Maybe you picked that sailing because it stopped in Santorini, Cozumel, or Nassau. Then, out of nowhere, the cruise line announces a port change. Suddenly, the destination you were most excited about is off the itinerary. Cruise lines have a lot of flexibility when it comes to changing itineraries, though there are still a few situations where refunds, credits, or reimbursements may come into play.